Biological act of element vanadium

[Masoud-s]

سوالات بي جوابي درباره ي عنصر واناديوم دارم كه ميخوام مطرح كنم! واناديوم فلزيه كه در موجودات ابزي اكثرا و كمتر در خشكي زي ها اهميت فراواني داره ...تونيكات ها سلول هاي خاصي به نام وانادوسيت دارن كه واناديوم رو به صورت متصل به پروتئين وانابين داره...به نظر شما وجود اين سلولا چه لزومي داره در تونيكات ها؟
اخيرا تحقيقاتي نشون داده كه واناديوم اثرات شبه انسوليني در انسان داره...سوال اينجاست كه چرا بايد يك عنصر نقش مشابه يك پروتئين رو داشته باشه؟ غير منطقي نيست؟
البته اين تاپيك شايد گزاره خبري هم محسوب بشه پس لطفا بحث كنيد كه تونيكات ها چرا اينقد تخصص يافتن واسه استفاده از واناديوم و چرا واناديوم اثرات شبه انسوليني داره؟

 

[Alice]

پاسخ : Biological act of element vanadium

[HR][/HR]ببخشید میشه یه توضیحی در مورد تونیکات بدین؟
ممنون.

 

[Masoud-s]

پاسخ : Biological act of element vanadium

[HR][/HR]ببخشید میشه یه توضیحی در مورد تونیکات بدین؟
ممنون.

تونيكات ها جزو اولين طنابداران هستند ولي مهره دار نيستند(جزو كورداتا هستند ولي vertebrate نيستند)

 

[Ardavan]

پاسخ : Biological act of element vanadium

این ها من را یاد مگنتوزوم انداخت !! یک سوال شاید بی ربط !؟! وانادیم فرومغناطیسه ، دیامغناطیسه یا پارامغناطیسه ؟!

 

[Masoud-s]

پاسخ : Biological act of element vanadium

پارامغناطيس فكر ميكنم......

 

[Ardavan]

پاسخ : Biological act of element vanadium

جدیدا مد شده همه چیز را به خاصیت انتی اکسیدان ربط می دن !:4: این شاید کمک می کنه به حذف رادیکال های ازاد !! دیگه بیش از این امشب به ذهنم نمی رسه !!

 

[Ardavan]

پاسخ : Biological act of element vanadium

من یک سوال مطرح می کن فکر می کنم گره گشا شاید باشه !!
علت سمیت وانادیم زیاد برای انسان چی هست ؟!

---- دو نوشته به هم متصل شده است ----

Vanadium is a potent inhibitor of many enzymes,
while it stimulates adenylate cyclase. It has been shown to inhibit cholesterol biosynthesis
and lower plasma cholesterol levels. Vanadium can also directly influence glucose
metabolism in vitro and may play a role in its regulation. Lipid peroxidation of rat lung
extracts, liver microsomes and mitochondria was induced by sulfite and accelerated by the
presence of vanadium compounds.
Vanadium may play a physiological role as part of a control on levels of the endogenous
antioxidant, glutathione. This may also be important with respect to toxic interactions of
chemicals (26).
​

یک ایده زدم انگار خیلی هم غلط نبوده !!! این دو خط اخر تاییدی بر حرفم !!

 

[Masoud-s]

پاسخ : Biological act of element vanadium

estimated daily intake of the US population ranges from 10-60 micrograms V. Vanadyl sulfate is a common supplement used to enhance weight training in athletes at doses up to 60 mg/d. In vitro and animal studies indicate that vanadate and other vanadium compounds increase glucose transport activity and improve glucose metabolism. In general, the toxicity of vanadium compounds is low. Pentavalent compounds are the most toxic and the toxicity of vanadium compounds usually increases as the valence increases. Most of the toxic effects of vanadium compounds result from local irritation of the eyes and upper respiratory tract rather than systemic toxicity. The only clearly documented effect of exposure to vanadium dust is upper respiratory tract irritation characterized by rhinitis, wheezing, nasal hemorrhage, conjunctivitis, cough, sore throat, and chest pain

 

[Ardavan]

پاسخ : Biological act of element vanadium

estimated daily intake of the US population ranges from 10-60 micrograms V. Vanadyl sulfate is a common supplement used to enhance weight training in athletes at doses up to 60 mg/d. In vitro and animal studies indicate that vanadate and other vanadium compounds increase glucose transport activity and improve glucose metabolism. In general, the toxicity of vanadium compounds is low. Pentavalent compounds are the most toxic and the toxicity of vanadium compounds usually increases as the valence increases. Most of the toxic effects of vanadium compounds result from local irritation of the eyes and upper respiratory tract rather than systemic toxicity. The only clearly documented effect of exposure to vanadium dust is upper respiratory tract irritation characterized by rhinitis, wheezing, nasal hemorrhage, conjunctivitis, cough, sore throat, and chest pain

این که دقیق نگفته کدوم انزیم را از کار می اندازه !! علایمش به چه دردم می خوره اخه !!!!!! :4:

 

[Ardavan]

پاسخ : Biological act of element vanadium

اه !!!!! :4: هر چیزی که فکر میکنی جوابش کشف نشده جوابش کشف شده !!!!! من نمی دونم برای دوران ما چیز کشف نشده چی می مونه !!!
این جواب سوال ! فقط مقالش purchase می خواد . البته تو abstract مکانیسم کلی این عملکردش را گفته .
Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component

Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component.
Abstract

Organovanadium compounds have been shown to be insulin sensitizers in vitro and in vivo. One potential biochemical mechanism for insulin sensitization by these compounds is that they inhibit protein tyrosine phosphatases (PTPs) that negatively regulate insulin receptor activation and signaling. In this study, bismaltolato oxovanadium (BMOV), a potent insulin sensitizer, was shown to be a reversible, competitive phosphatase inhibitor that inhibited phosphatase activity in cultured cells and enhanced insulin receptor activation in vivo. NMR and X-ray crystallographic studies of the interaction of BMOV with two different phosphatases, HCPTPA (human low molecular weight cytoplasmic protein tyrosine phosphatase) and PTP1B (protein tyrosine phosphatase 1B), demonstrated uncomplexed vanadium (VO(4)) in the active site. Taken together, these findings support phosphatase inhibition as a mechanism for insulin sensitization by BMOV and other organovanadium compounds and strongly suggest that uncomplexed vanadium is the active component of these compounds.​

---- دو نوشته به هم متصل شده است ----

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